Dr. Liu’s research focuses on computational proteomics, especially mass spectrometry-based top-down proteomics, which can identify various proteoforms with alterations in biological samples. His lab designed innovative algorithms and developed the most popular open-source software suite for top-down MS-based proteoform identification, characterization, and quantification, which has been used by hundreds of universities and research institutes. These software tools, including TopFD, TopPIC, and TopMG, significantly facilitate the application of top-down mass spectrometry in disease biomarker discovery, proteoform database annotation, and protein function studies. Dr. Liu’s lab is supported by several NIH grants, and his work has resulted in more than 60 peer-reviewed journal papers.